Anti-Exportin T antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Application

Anti-Exportin T antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Exportin-T acts as a specific mediator of tRNA export. Exportin-T is a RanGTP-binding, importin β-related factor with predominantly nuclear localization that shuttles rapidly between nucleus and cytoplasm. It interacts with nuclear pore complexes as well. Exportin-t binds tRNA directly and with high affinity. It is responsible for majority of tRNA export in cells and plays an essential role in the transport of tRNA. It is associated with intracellular tRNA trafficking and is in turn associated with discrete changes in the composition of cellular cytoplasmic multi-protein complexes containing tRNA.

General description

XPOT (exportin T) is a tRNA nuclear export receptor found in vertebrates. This protein shuttles between the cytoplasm and nucleus. It belongs to the importin-β family, and has a distant relation to Los1p protein found in yeast.

Immunogen

Immunogen Sequence: GI # 8051636, sequence 5-234

Recombinant TRNA exportin

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.